FORMULATION AND EVALUATION OF PHYTOSOMAL GEL OF MORINDA CITRIFOLIA EXTRACT FOR ENHANCED TOPICAL DELIVERY

Authors

  • Lalita Sharma PG Scholar, College of Pharmacy, Dr. APJ Abdul Kalam University, Indore
  • Dr. Ragini Bundela Professor, College of Pharmacy, Dr. APJ Abdul Kalam University, Indore
  • Dr. Karunakar Shukla Professor, College of Pharmacy, Dr. APJ Abdul Kalam University, Indore
  • Dr. Neha Jain Visiting Research Associate, Pinnacle Biomedical Research Institute, Bhopal MP India

Keywords:

Spread ability, F1 Formulation, Morinda Citrifolia, Phytosomes, Drug

Abstract

The study aimed to enhance the solubility, bioavailability, and skin permeation of Morinda citrifolia extract by formulating it into phytosomes using the antisolvent precipitation technique and incorporating these into topical gels. The plant extract was initially prepared via Soxhlet extraction using ethanol, followed by rotary evaporation. Phytosomes were formed at varying molar ratios of drug to phospholipid (1:1 to 1:7) and characterized by optical microscopy, entrapment efficiency, drug content, solubility, and in-vitro drug diffusion studies. Among all formulations, F1 (1:1 ratio) exhibited optimal characteristics, including the highest drug entrapment efficiency (89.87%), drug content (88.43%), and cumulative drug release (91.23% in 10 hours). This optimized phytosomal complex was then incorporated into Carbopol 934-based gels, evaluated for pH, homogeneity, viscosity, spreadability, extrudability, and in-vitro release. The F1 gel formulation showed excellent drug content (90.29%), spreadability (4.1 cm), and cumulative drug release (89.35% in 12 hours), with sustained release following Higuchi kinetics and a non-Fickian diffusion mechanism. Stability studies confirmed the formulation’s physical and chemical stability over 45 days. Overall, the phytosomal gel of Morinda citrifolia demonstrates promising potential for enhanced dermal drug delivery.

References

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Published

07-07-2023

How to Cite

Sharma, L., Bundela, R., Shukla, K., & Jain, D. N. (2023). FORMULATION AND EVALUATION OF PHYTOSOMAL GEL OF MORINDA CITRIFOLIA EXTRACT FOR ENHANCED TOPICAL DELIVERY. American Journal of Medical Science and Chemical Research, 5(07), 01–19. Retrieved from http://journaloms.com/index.php/ojs/article/view/13

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Vol. 5 No. 07 (2023): July 2023

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Copyright (c) 2023 Lalita Sharma, Dr. Ragini Bundela, Dr. Karunakar Shukla, Dr. Neha Jain

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